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Chemotherapy may spread cancer and trigger more aggressive tumours, warn scientists

Chemotherapy may spread cancer and trigger more aggressive tumours, warn scientists

 

Chemotherapy could allow cancer to spread, and trigger more aggressive tumours, a new study suggests.

Researchers in the US studied the impact of drugs on patients with breast cancer and found medication increases the chance of cancer cells migrating to other parts of the body, where they are almost always lethal.

Around 55,000 women are diagnosed with breast cancer in Britain every year and 11,000 will die from their illness.

 Many are given chemotherapy before surgery, but the new research suggests that, although it shrinks tumours in the short term, it could trigger the spread of cancer cells around the body.

It is thought the toxic medication switches on a repair mechanism in the body which ultimately allows tumours to grow back stronger. It also increases the number of ‘doorways’ on blood vessels which allow cancer to spread throughout the body.

An image showing 'doorways' opening in blood vessels which allow tumours to spread 
An image showing ‘doorways’ opening in blood vessels which allow tumours to spread  Credit: George Karagiannis 

Dr George Karagiannis, of the Albert Einstein College of Medicine of Yeshiva University, New York, found the number of doorways was increased in 20 patients receiving two common chemotherapy drugs.

He also discovered that in mice, breast cancer chemotherapy increased the number of cancer cells circulating the body and in the lungs.

Dr Karagiannis said women could be monitored during chemotherapy to check if cancer was starting to circulate and doorways were emerging.

“One approach would be to obtain a small amount of tumour tissue after a few doses of preoperative chemotherapy,” he said.

“If we observe that the markers scores are increased we would recommend discontinuing chemo and having surgery first, followed by post-operative chemo. We are currently planning more extensive trials to address the issue.

“In this study we only investigated chemotherapy-induced cancer cell dissemination in breast cancer. We are currently working on other types of cancer to see if similar effects are elicited.”

The study was published in the journal Science Translational Medicine.

Saturday Morning Radio with Kim Hill 2nd May 2009: Cancer Researcher, Paul Talalay

On the Kim Hill Show at 8:10am is cancer zbc0330710000001researcher Paul Talalay, M.D.  He is the John Jacob Abel Distinguished Service Professor of Pharmacology and Director of the Laboratory for Molecular Sciences at Johns Hopkins University School of Medicine in Baltimore. He also is the founder of The Brassica Chemoprotection Laboratory, which is dedicated to studying edible plants that induce protective enzyme activity in the body and may help prevent cancer development. He is visiting New Zealand to deliver a lecture at a conference on scientific research at Auckland University.
www.hopkinsmedicine.org/pharmacology/research/talalay.html
https://www.brassica.com/coinfo/bio_ptalalay.htm

Check out the website page at www.radionz.co.nz/saturday for more information about featured guests, books, music or recipes featured on the programme, live streaming audio, four weeks’ worth of archived audio from recent programmes, and podcasts.

Marijuana Chemical Cannabidiol Halts Spread of Breast Cancer Tumors

https://www.naturalnews.com/023340.htm

(NaturalNews) A non-psychoactive chemical that occurs naturally in the marijuana plant may prevent breast cancer from spreading, according to a study published in the journal Molecular Cancer Therapeutics.

Researchers found that a chemical called cannabidiol (CBD) affects the activity of a gene known as Id-1 in patients with hormone-independent breast cancer. In embryos, Id-1 is responsible for helping cells grow and spread, but is supposed to remain inactive in adults. In human adults, it is found only in metastatic cancer cells, or cancer cells that are spreading throughout the body.
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